EXPRESSION DYNAMICS OF PERIODIC TRANSCRIPTS DURING CANCER CELL CYCLE PROGRESSION AND THEIR CORRELATION WITH ANTICANCER DRUG SENSITIVITY

Expression dynamics of periodic transcripts during cancer cell cycle progression and their correlation with anticancer drug sensitivity

Abstract Background The cell cycle is at the center of cellular activities and is orchestrated by complex regulatory mechanisms, among which transcriptional regulation is one of the most important components.Alternative splicing dramatically expands the regulatory network by producing transcript isoforms of genes to exquisitely control the cell cyc

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